LMPD Database

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LMP012992

UniProt Annotations

Entry Information
Gene Namedehydrogenase/reductase (SDR family) member 4
Protein EntryDHRS4_RAT
UniProt IDQ8VID1
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityR-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
FunctionReduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)
MiscellaneousInhibited by kaempferol, quercetin, genistein and myristic acid
Sequence CautionSequence=BAB78529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationPeroxisome .
SubunitHomotetramer