LMPD Database

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LMP012878

UniProt Annotations

Entry Information
Gene Namepost-GPI attachment to proteins 2
Protein EntryPGAP2_RAT
UniProt IDQ2ABP3
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2ABP3-1; Sequence=Displayed; Name=2; IsoId=Q2ABP3-2; Sequence=VSP_032554;
FunctionInvolved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface
MiscellaneousIn osteosarcoma cells, a chromosomal translocation with FGFR2 results in an in-frame fusion of the two genes. This generates FGFR2-ROS, a chimeric protein with transforming activity.
Sequence CautionSequence=AAB07050.1; Type=Frameshift; Positions=250; Evidence= ;
SimilarityBelongs to the PGAP2 family
Subcellular LocationGolgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitInteracts with PGAP2IP
Tissue SpecificityExpressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis