LMPD Database

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LMP012842

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 3, neutral membrane
Protein EntryNSMA2_RAT
UniProt IDO35049
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
FunctionCatalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions
PathwayLipid metabolism; sphingolipid metabolism.
PtmPalmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation
Sequence CautionSequence=BAA22932.1; Type=Frameshift; Positions=616; Evidence= ;
SimilarityBelongs to the neutral sphingomyelinase family
Subcellular LocationGolgi apparatus membrane; Lipid-anchor. Cell membrane {ECO:0000250}; Lipid-anchor . Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons
Tissue SpecificityIn brain sections, it is restricted to neurons and especially prominent in large cells, including Purkinje cells, pyramidal cells, neurons of the dentate gyrus granular layer, and neurons in the pontine nuclei. Also present in the hypothalamic nuclei, neurons in the piriform cortex, and nuclei of the brainstem (at protein level). Mainly expressed in brain and jejunum. Weakly or not expressed in heart, spleen, lung, liver, kidney and testis