LMPD Database

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LMP012818

UniProt Annotations

Entry Information
Gene Namefatty acid desaturase 1
Protein EntryFADS1_RAT
UniProt IDQ920R3
SpeciesRat
Comments
Comment typeDescription
DomainThe histidine box domains may contain the active site and/or be involved in metal ion binding.
FunctionComponent of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity)
InductionRegulated by dietary vitamin A and exogenous retinoic acid in liver
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis.
SimilarityBelongs to the fatty acid desaturase family
SimilarityContains 1 cytochrome b5 heme-binding domain
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Mitochondrion .
Tissue SpecificityHighly abundant in adrenal gland and mammary tissue and moderately in liver, kidney, lung, spleen, thymus, brain, and eye