LMPD Database

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LMP012808

UniProt Annotations

Entry Information
Gene Nameparaoxonase 1
Protein EntryPON1_RAT
UniProt IDP55159
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityAn aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol.
Catalytic ActivityAn N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine.
Catalytic ActivityA phenyl acetate + H(2)O = a phenol + acetate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ;
FunctionHydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity)
MiscellaneousThe preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces (By similarity)
PtmGlycosylated
PtmThe signal sequence is not cleaved.
SimilarityBelongs to the paraoxonase family
Subcellular LocationSecreted, extracellular space.
SubunitHomodimer. Interacts with CLU (By similarity)
Tissue SpecificityPlasma. Associated with HDL.