LMPD Database

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LMP012747

UniProt Annotations

Entry Information
Gene Namehydroxyprostaglandin dehydrogenase 15 (NAD)
Protein EntryPGDH_RAT
UniProt IDO08699
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost- 5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15- dioxoprost-5,13-dienoate + NADH.
FunctionProstaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationCytoplasm .
SubunitHomodimer