LMPD Database

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LMP012731

UniProt Annotations

Entry Information
Gene NameArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Protein EntryAGAP2_RAT
UniProt IDQ8CGU4
SpeciesRat
Comments
Comment typeDescription
DomainArf-GAP domain interacts with G domain and may regulate its GTPase activity
DomainG domain binds GTP and has GTPase activity
DomainPH domain binds phospholipids and is required for nuclear targeting
Enzyme RegulationGAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation (By similarity)
FunctionGTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. {ECO:0000269|PubMed:11136977, ECO:0000269|PubMed:11823862, ECO:0000269|PubMed:15385964, ECO:0000269|PubMed:16263930}.
InteractionQ63155:Dcc; NbExp=2; IntAct=EBI-4409108, EBI-1798965; P19491:Gria2; NbExp=4; IntAct=EBI-4409108, EBI-77718; P97879:Grip1; NbExp=4; IntAct=EBI-4409108, EBI-936113; Q9Z214-1:Homer1; NbExp=4; IntAct=EBI-4409108, EBI-4410552; Q8IZJ1:UNC5B (xeno); NbExp=9; IntAct=EBI-4409108, EBI-4409075; O08722:Unc5b; NbExp=6; IntAct=EBI-4409108, EBI-4404185;
Sequence CautionSequence=AAF97595.1; Type=Frameshift; Positions=Several; Note=This sequence would represent a shorter strictly nuclear isoform named PIKE-S. It may be an artifactual frameshifted form whose existence in vivo is dubious.; Evidence= ;
SimilarityBelongs to the centaurin gamma-like family
SimilarityContains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm. Nucleus.
SubunitInteracts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2. {ECO:0000269|PubMed:11136977, ECO:0000269|PubMed:11823862, ECO:0000269|PubMed:14528310, ECO:0000269|PubMed:15598747}.
Tissue SpecificityPresent in cortex, hippocampus and olfactory bulb but absent in cerebellum (at protein level)