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LMPD Database

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LMP012686

UniProt Annotations

Entry Information

Gene Name	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Protein Entry	PHAG1_RAT
UniProt ID	Q9JM80
Species	Rat

Comments

Comment type	Description
Caution	In contrast to the human ortholog, does not seem to interact with FYN
Caution	In contrast to the human ortholog, does not seem to interact with FYN. {ECO:0000305\|PubMed:10801129}.
Function	Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:10918051, ECO:0000269\|PubMed:11859092}.
Ptm	Palmitoylated
Ptm	Palmitoylated. {ECO:0000250}.
Ptm	Phosphorylated by FYN on Tyr-314 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN in response to EPO. {ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:10918051, ECO:0000269\|PubMed:11859092, ECO:0000269\|PubMed:14613929, ECO:0000269\|PubMed:16920712}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:11859092}; Single-pass type III membrane protein {ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:11859092}. Note=Present in lipid rafts.
Subunit	Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). When phosphorylated, interacts with CSK. Identified in a complex with LYN and STAT3 (By similarity). Interacts with LYN. {ECO:0000250, ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:11859092, ECO:0000269\|PubMed:14613929, ECO:0000269\|PubMed:16920712}.
Tissue Specificity	Ubiquitously expressed, with highest levels in developing brain, lung, thymus, spleen and testis. Present in mast cells
Tissue Specificity	Ubiquitously expressed, with highest levels in developing brain, lung, thymus, spleen and testis. Present in mast cells. {ECO:0000269\|PubMed:10801129, ECO:0000269\|PubMed:11859092}.