LMPD Database

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LMP012676

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase 1
Protein EntryGDE1_RAT
UniProt IDQ9JL55
SpeciesRat
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=12 mM for glycerophosphoinositol ; Vmax=3000 pmol/min/mg enzyme ; Note=Measured in the presence of 10 mM magnesium chloride at 37 degrees Celsius.;
Catalytic Activity1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
FunctionHas glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways
PtmN-glycosylated
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family
SimilarityContains 1 GP-PDE domain
Subcellular LocationCytoplasm. Membrane; Multi-pass membrane protein. Note=Perinuclear vesicles and cell membrane.
SubunitInteracts with PRAF2 (By similarity). Interacts with RGS16
Tissue SpecificityDetected in heart, brain, lung, liver, skeletal muscle, kidney, pituitary and testis