LMPD Database

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LMP012663

UniProt Annotations

Entry Information
Gene Namefucosyltransferase 2 (secretor status included)
Protein EntryFUT2_RAT
UniProt IDQ10984
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q10984-1; Sequence=Displayed; Name=2; IsoId=Q10984-2; Sequence=VSP_016526;
Catalytic ActivityGDP-beta-L-fucose + beta-D-galactosyl-(1->3)- N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta- D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D- galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
FunctionCreates a membrane-associated precursor oligosaccharide Fuc-alpha((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the membrane-associated A and B antigen synthesis pathway
MiscellaneousIn rat, there are three genes (Fut1/Fta, Fut2/Ftb and Ftc) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner and Ftc may have no enzymatic activity.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 11 family
Subcellular LocationGolgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein . Note=Membrane-bound form in trans cisternae of Golgi
Tissue SpecificitySpecifically expressed in gut