LMPD Database

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LMP012658

UniProt Annotations

Entry Information
Gene Namearylacetamide deacetylase
Protein EntryAAAD_RAT
UniProt IDQ9QZH8
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionDisplays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000250, ECO:0000269|PubMed:22207054}.
SimilarityBelongs to the 'GDXG' lipolytic enzyme family
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein . Microsome membrane ; Single-pass type II membrane protein .
Tissue SpecificityHighest levels in liver with lower levels in jejunum, kidney and testis