LMPD Database

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LMP012653

UniProt Annotations

Entry Information
Gene Namepyruvate dehyrogenase phosphatase catalytic subunit 1
Protein Entry
UniProt ID
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17532339}; Note=Binds 2 magnesium ions per subunit. {ECO:0000269|PubMed:17532339};
FunctionCatalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
SimilarityBelongs to the PP2C family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHeterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit. {ECO:0000269|PubMed:17532339}.
Tissue SpecificityHighly expressed in skeletal muscle.