LMPD Database

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LMP012639

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 1
Protein EntryACOT1_RAT
UniProt IDO88267
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + H(2)O = CoA + palmitate.
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16.
InductionIn the liver, by peroxisome proliferator (Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours.
SimilarityBelongs to the C/M/P thioester hydrolase family
Subcellular LocationCytoplasm.
SubunitMonomer.
Tissue SpecificityExpressed in liver.