LMPD Database

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LMP012596

UniProt Annotations

Entry Information
Gene Nameamine oxidase, copper containing 3
Protein EntryAOC3_RAT
UniProt IDO08590
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityRCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ;
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence= ; Note=Binds 1 copper ion per subunit. ;
CofactorName=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence= ; Note=Contains 1 topaquinone per subunit. ;
FunctionCell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity)
PtmN- and O-glycosylated
PtmTopaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
SimilarityBelongs to the copper/topaquinone oxidase family
Subcellular LocationMembrane {ECO:0000269|PubMed:8520629, ECO:0000269|PubMed:9083076}; Single-pass type II membrane protein .
SubunitHomodimer; disulfide-linked. Forms a heterodimer with AOC2 (By similarity)
Tissue SpecificityHighly expressed in adipocytes, aorta and lung. Expressed at lower levels in heart, kidney, large intestine, liver, small intestine and stomach