LMPD Database

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LMP012570

UniProt Annotations

Entry Information
Gene Namecarbonyl reductase 1
Protein EntryCBR1_RAT
UniProt IDP47727
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost- 13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13- enoate + NADPH.
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11- alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
Catalytic ActivityR-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
FunctionNADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity)
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationCytoplasm.
SubunitMonomer