LMPD Database

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LMP012537

UniProt Annotations

Entry Information
Gene Nameperilipin 1
Protein EntryPLIN1_RAT
UniProt IDP43884
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A; Synonyms=PERIA; IsoId=P43884-1; Sequence=Displayed; Name=B; Synonyms=PERIB; IsoId=P43884-2; Sequence=VSP_004662, VSP_004663;
FunctionModulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels (By similarity)
PtmMajor cAMP-dependent protein kinase substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL. When unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet
PtmThe N-terminus is blocked.
SimilarityBelongs to the perilipin family
Subcellular LocationEndoplasmic reticulum . Lipid droplet. Note=Lipid droplet surface-associated.
SubunitInteracts with ABHD5. Interacts with CIDEC (By similarity)
Tissue SpecificityAdipocytes.
Web ResourceName=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="http://web.expasy.org/spotlight/back_issues/010";