LMPD Database

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LMP012528

UniProt Annotations

Entry Information
Gene Nametocopherol (alpha) transfer protein
Protein EntryTTPA_RAT
UniProt IDP41034
SpeciesRat
Comments
Comment typeDescription
FunctionBinds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)
SimilarityContains 1 CRAL-TRIO domain. {ECO:0000255|PROSITE- ProRule:PRU00056}.
Subcellular LocationCytoplasm.
SubunitMonomer and homotetramer. Phosphatidylinol 4,5- bisphosphate binding induces the formation of homotetramers. Phosphatidylinol 3,4-bisphosphate is less efficient in inducing tetramerization (By similarity)
Tissue SpecificityLiver.