LMPD Database

LMP012507

Gene Information

Entrez Gene ID	25404
Gene Name	caveolin 1, caveolae protein
Gene Symbol	Cav1
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0002080	IEA:Ensembl	C	acrosomal membrane
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0016323	IEA:Ensembl	C	basolateral plasma membrane
GO:0005901	IEA:UniProtKB-SubCell	C	caveola
GO:0005938	IEA:Ensembl	C	cell cortex
GO:0005929	IEA:Ensembl	C	cilium
GO:0005783	IEA:Ensembl	C	endoplasmic reticulum
GO:0005768	IEA:Ensembl	C	endosome
GO:0000139	IEA:UniProtKB-SubCell	C	Golgi membrane
GO:0005887	IEA:Ensembl	C	integral component of plasma membrane
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0043234	IEA:Ensembl	C	protein complex
GO:0016504	IEA:Ensembl	F	peptidase activator activity
GO:0005198	IEA:Ensembl	F	structural molecule activity
GO:0001525	IEA:Ensembl	P	angiogenesis
GO:0097190	IEA:Ensembl	P	apoptotic signaling pathway
GO:0006816	IEA:Ensembl	P	calcium ion transport
GO:0070836	IEA:Ensembl	P	caveola assembly
GO:0072584	IEA:Ensembl	P	caveolin-mediated endocytosis
GO:0071455	IEA:Ensembl	P	cellular response to hyperoxia
GO:0009267	IEA:Ensembl	P	cellular response to starvation
GO:0042632	IEA:Ensembl	P	cholesterol homeostasis
GO:0051480	IEA:Ensembl	P	cytosolic calcium ion homeostasis
GO:0000188	IEA:Ensembl	P	inactivation of MAPK activity
GO:0007595	IEA:Ensembl	P	lactation
GO:0019915	IEA:Ensembl	P	lipid storage
GO:0060056	IEA:Ensembl	P	mammary gland involution
GO:0000165	IEA:Ensembl	P	MAPK cascade
GO:0051899	IEA:Ensembl	P	membrane depolarization
GO:2000811	IEA:Ensembl	P	negative regulation of anoikis
GO:0030514	IEA:Ensembl	P	negative regulation of BMP signaling pathway
GO:0090090	IEA:Ensembl	P	negative regulation of canonical Wnt signaling pathway
GO:0001960	IEA:Ensembl	P	negative regulation of cytokine-mediated signaling pathway
GO:0001937	IEA:Ensembl	P	negative regulation of endothelial cell proliferation
GO:0030857	IEA:Ensembl	P	negative regulation of epithelial cell differentiation
GO:0045019	IEA:Ensembl	P	negative regulation of nitric oxide biosynthetic process
GO:0051001	IEA:Ensembl	P	negative regulation of nitric-oxide synthase activity
GO:0033137	IEA:Ensembl	P	negative regulation of peptidyl-serine phosphorylation
GO:0048550	IEA:Ensembl	P	negative regulation of pinocytosis
GO:0032091	IEA:Ensembl	P	negative regulation of protein binding
GO:0031397	IEA:Ensembl	P	negative regulation of protein ubiquitination
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0042524	IEA:Ensembl	P	negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0033484	IEA:Ensembl	P	nitric oxide homeostasis
GO:0010524	IEA:Ensembl	P	positive regulation of calcium ion transport into cytosol
GO:0090263	IEA:Ensembl	P	positive regulation of canonical Wnt signaling pathway
GO:2001238	IEA:Ensembl	P	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	IEA:Ensembl	P	positive regulation of intrinsic apoptotic signaling pathway
GO:0048554	IEA:Ensembl	P	positive regulation of metalloenzyme activity
GO:0033138	IEA:Ensembl	P	positive regulation of peptidyl-serine phosphorylation
GO:0045907	IEA:Ensembl	P	positive regulation of vasoconstriction
GO:0051260	IEA:Ensembl	P	protein homooligomerization
GO:0008104	IEA:Ensembl	P	protein localization
GO:2000286	IEA:Ensembl	P	receptor internalization involved in canonical Wnt signaling pathway
GO:0030193	IEA:Ensembl	P	regulation of blood coagulation
GO:0019217	IEA:Ensembl	P	regulation of fatty acid metabolic process
GO:0006940	IEA:Ensembl	P	regulation of smooth muscle contraction
GO:0003057	IEA:Ensembl	P	regulation of the force of heart contraction by chemical signal
GO:0051592	IEA:Ensembl	P	response to calcium ion
GO:0043627	IEA:Ensembl	P	response to estrogen
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0002931	IEA:Ensembl	P	response to ischemia
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0007519	IEA:Ensembl	P	skeletal muscle tissue development
GO:0031295	IEA:Ensembl	P	T cell costimulation
GO:0006641	IEA:Ensembl	P	triglyceride metabolic process
GO:0001570	IEA:Ensembl	P	vasculogenesis
GO:0042310	IEA:Ensembl	P	vasoconstriction
GO:0016050	IEA:Ensembl	P	vesicle organization

KEGG Pathway Links

KEGG Pathway ID	Description
ko05100	Bacterial invasion of epithelial cells
rno05100	Bacterial invasion of epithelial cells
ko04144	Endocytosis
rno04144	Endocytosis
ko04510	Focal adhesion
rno04510	Focal adhesion
ko05205	Proteoglycans in cancer
rno05205	Proteoglycans in cancer
rno05416	Viral myocarditis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5954052	Basigin interactions
5953650	Cell surface interactions at the vascular wall
5954029	disassembly of the destruction complex and recruitment of AXIN to the membrane
5953253	Disease
5954032	eNOS activation
5954033	eNOS activation and regulation
5953645	Hemostasis
5953753	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
5953754	Lipid digestion, mobilization, and transport
5953250	Metabolism
5953289	Metabolism of lipids and lipoproteins
5954034	Metabolism of nitric oxide
5954026	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
5954043	NOSTRIN mediated eNOS trafficking
5954027	RNF mutants show enhanced WNT signaling and proliferation
5953420	Signaling by VEGF
5953803	Signaling by Wnt
5953965	Signaling by WNT in cancer
5953381	Signal Transduction
5954025	TCF dependent signaling in response to WNT
5953419	VEGFA-VEGFR2 Pathway
5953999	VEGFR2 mediated vascular permeability
5954028	XAV939 inhibits tankyrase, stabilizing AXIN