LMPD Database

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LMP012401

UniProt Annotations

Entry Information
Gene Nameendothelin receptor type A
Protein EntryEDNRA_RAT
UniProt IDP26684
SpeciesRat
Comments
Comment typeDescription
FunctionReceptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
SimilarityBelongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with HDAC7 and KAT5
Tissue SpecificityPredominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.