LMPD Database

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LMP012371

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase, small subunit A
Protein Entry
UniProt IDQ969W0
SpeciesHuman
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-4 is the initiator
FunctionStimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=AAH16805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH16808.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH21701.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAH68480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAG37801.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the SPTSS family. SPTSSA subfamily
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein
SubunitInteracts with SPTLC1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB