LMPD Database

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LMP012363

Record overview

LMPD IDLMP012363
Gene ID93210
SpeciesHomo sapiens (Human)
Gene Namepost-GPI attachment to proteins 3
Gene SymbolPGAP3
SynonymsCAB2; PERLD1; PP1498; hCOS16; AGLA546;
Chromosome17
Map Location17q12
SummaryThis gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause the autosomal recessive neurologic disorder hyperphosphatasia with mental retardation syndrome 4 (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for PGAP3

Proteins

post-GPI attachment to proteins factor 3 isoform 1 precursor
Refseq ID:NP_219487
Protein GI:45505180
UniProt ID:Q96FM1
mRNA ID:NM_033419
Length:320
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFL
FFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFR
ALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFS
FLEDDSLYLLKESEDKFKLD
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1797
peptide sequence: 
MAGLAARLVLLAGAAALASG
mat_peptide: 21..320
product: Post-GPI attachment to proteins factor 3
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q96FM1.2)
calculated_mol_wt: 34696
peptide sequence: 
SQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLV
MLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFD
YGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD
 
post-GPI attachment to proteins factor 3 isoform 2 precursor
Refseq ID:NP_001278655
Protein GI:619726944
UniProt ID:Q96FM1
mRNA ID:NM_001291726
Length:269
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKVSLNAWF
WSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLP
HVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD
 
post-GPI attachment to proteins factor 3 isoform 3 precursor
Refseq ID:NP_001278657
Protein GI:619328895
UniProt ID:Q96FM1
mRNA ID:NM_001291728
Length:299
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFL
FFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDY
GYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD
 
post-GPI attachment to proteins factor 3 isoform 4 precursor
Refseq ID:NP_001278659
Protein GI:619328939
UniProt ID:Q96FM1
mRNA ID:NM_001291730
Length:206
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFL
FFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVSFLEDDSLYLLKESE
DKFKLD
 
post-GPI attachment to proteins factor 3 isoform 5 precursor
Refseq ID:NP_001278661
Protein GI:619328971
UniProt ID:Q96FM1
mRNA ID:NM_001291732
Length:185
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFL
FFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWKMDYFCASTVILHSIYLCCVSFLEDDSLYLLKESEDKFKLD
 
post-GPI attachment to proteins factor 3 isoform 6 precursor
Refseq ID:NP_001278662
Protein GI:619328947
UniProt ID:Q96FM1
mRNA ID:NM_001291733
Length:148
RefSeq Status:
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFL
FFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWLSGR