LMPD Database

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LMP012221

UniProt Annotations

Entry Information
Gene Namezinc finger, FYVE domain containing 28
Protein EntryLST2_DANRE
UniProt IDA0JMD2
SpeciesZebrafish
Comments
Comment typeDescription
DomainThe FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87. {ECO:0000250}.
FunctionNegative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity). {ECO:0000250}.
PtmMonoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. {ECO:0000250}.
SimilarityBelongs to the lst-2 family. {ECO:0000305}.
SimilarityContains 1 FYVE-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00091}.
Subcellular LocationCytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated (By similarity). {ECO:0000250}.