LMPD Database

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LMP011908

UniProt Annotations

Entry Information
Gene NameN-acylsphingosine amidohydrolase 2
Protein EntryASAH2_DANRE
UniProt IDQ5W7F1
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityN-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Disruption PhenotypeFishes display severe embryonic morphological and cellular abnormalities such as abnormal morphogenesis in the head and tail, pericardiac edema, defect of blood cell circulation, and an increase of apoptotic cells, especially in the head and neural tube regions, at 36 hours post- fertilization. {ECO:0000269|PubMed:15271994}.
FunctionHydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Essential for the metabolism of ceramide and the early development. {ECO:0000269|PubMed:15271994}.
PtmN-glycosylated. {ECO:0000269|PubMed:15271994}.
PtmO-glycosylated. {ECO:0000269|PubMed:15271994}.
SimilarityBelongs to the neutral ceramidase family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15271994}; Single-pass type II membrane protein {ECO:0000269|PubMed:15271994}.