LMPD Database

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LMP011893

UniProt Annotations

Entry Information
Gene NameCTD nuclear envelope phosphatase 1a
Protein EntryCNEPA_DANRE
UniProt IDQ5U395
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
FunctionSerine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity). {ECO:0000250}.
SimilarityBelongs to the dullard family. {ECO:0000305}.
SimilarityContains 1 FCP1 homology domain. {ECO:0000255|PROSITE- ProRule:PRU00336}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.