LMPD Database

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LMP011386

UniProt Annotations

Entry Information
Gene Nametranscription factor PIF1
Protein EntryPIF1_ARATH
UniProt IDQ8GZM7
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8GZM7-1; Sequence=Displayed; Name=2; IsoId=Q8GZM7-2; Sequence=VSP_036107; Note=May be due to a competing acceptor splice site. No experimental confirmation available.;
Disruption PhenotypePlants overaccumulate free protochlorophyllide in the darkness and exhibit photooxidative damage (bleaching) in subsequent light, probably caused by the photosensitizing activity of this tetrapyrrole intermediate. {ECO:0000269|PubMed:15448264, ECO:0000269|PubMed:18591656}.
FunctionTranscription activator. Regulates negatively chlorophyll biosynthesis and seed germination in the dark, and lightinduced degradation of PIF1 relieves this negative regulation to promote photomorphogenesis. Binds to the G-box motif (5'- CACGTG-3') found in many light-regulated promoters. Promotes the expression of SOM, and thus modulates responses to abscisic acid (ABA) and gibberellic acid (GA). {ECO:0000269|PubMed:15448264, ECO:0000269|PubMed:16359394, ECO:0000269|PubMed:18487351, ECO:0000269|PubMed:18539749, ECO:0000269|PubMed:18591656}.
InductionRepressed by red (R) and far red (FR) light treatments in a phyB- and phyA-dependent manner. {ECO:0000269|PubMed:15448264}.
InteractionSelf; NbExp=3; IntAct=EBI-630400, EBI-630400; Q9FE22:HFR1; NbExp=3; IntAct=EBI-630400, EBI-626001; P14713:PHYB; NbExp=3; IntAct=EBI-630400, EBI-300727; O80536:PIF3; NbExp=6; IntAct=EBI-630400, EBI-625701;
PtmPhosphorylated and ubiquitinated after an exposure to light (especially red and far-red), in a phytochrome-dependent manner. Modified proteins undergo a proteasome-dependent degradation. Its stability and degradation plays a central role in photomorphogenesis of seedlings. {ECO:0000269|PubMed:16359394, ECO:0000269|PubMed:18539749}.
Sequence CautionSequence=AAD24380.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:15448264, ECO:0000269|PubMed:16359394}.
SubunitHomodimer (Probable). Interacts with the photoactivated conformer (Pfr) of phytochromes A and B, PHYA and PHYB. Interacts also with APRR1/TOC1. Binds to RGL2, RGA and FHY3 (via N- terminus). {ECO:0000269|PubMed:12826627, ECO:0000269|PubMed:15448264, ECO:0000269|PubMed:18539749, ECO:0000269|PubMed:20093430, ECO:0000269|PubMed:22634759, ECO:0000305}.
Tissue SpecificityExpressed constitutively in roots, leaves, stems, and flowers. {ECO:0000269|PubMed:12679534}.