LMPD Database

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LMP011133

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 2C 77
Protein EntryP2C77_ARATH
UniProt IDO04719
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O04719-1; Sequence=Displayed; Name=2; IsoId=O04719-2; Sequence=VSP_034834; Note=Derived from EST data. No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 8. {ECO:0000269|PubMed:11882947};
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11882947}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:11882947}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000269|PubMed:11882947};
DomainThe 'lock' site stabilizes the complex made of PP2C, ABA and PYR/PYL/RCAR receptor by keeping receptor 'gate' and 'latch' loops in closed positions. {ECO:0000250}.
Enzyme RegulationPhosphatase activity repressed by oxidized ATGPX3, free fatty acids (e.g. arachidonic acid (20:4) and Linolenic acid (18:3)) and by H(2)O(2). Repressed by PYR/PYL/RCAR ABA receptors in an ABA-dependent manner. {ECO:0000269|PubMed:11882947, ECO:0000269|PubMed:19407142, ECO:0000269|PubMed:19769575}.
FunctionRepressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration. Controls negatively fibrillin that is involved in mediating ABA- induced photoprotection. May be implicated in ABA content regulation. Involved in acquired thermotolerance of root growth and seedling survival. Required for the Erwinia amylovora harpin- induced (HrpN) drought tolerance. Involved in the hydrotropic response. {ECO:0000269|PubMed:10488243, ECO:0000269|PubMed:10872217, ECO:0000269|PubMed:10950871, ECO:0000269|PubMed:11208021, ECO:0000269|PubMed:11701885, ECO:0000269|PubMed:11707572, ECO:0000269|PubMed:12119381, ECO:0000269|PubMed:12194854, ECO:0000269|PubMed:12232276, ECO:0000269|PubMed:12447533, ECO:0000269|PubMed:12609042, ECO:0000269|PubMed:14576281, ECO:0000269|PubMed:14596925, ECO:0000269|PubMed:15599761, ECO:0000269|PubMed:15923322, ECO:0000269|PubMed:16339784, ECO:0000269|PubMed:16571665, ECO:0000269|PubMed:18278579, ECO:0000269|PubMed:8787023, ECO:0000269|PubMed:9090884, ECO:0000269|PubMed:9108297, ECO:0000269|PubMed:9165752, ECO:0000269|PubMed:9276963}.
InductionRepressed by MYB44 and ERF4. Induced by salt stress and ABA. {ECO:0000269|PubMed:14731256, ECO:0000269|PubMed:16021341, ECO:0000269|PubMed:16998070, ECO:0000269|PubMed:18162593}.
InteractionQ9LDI3:CIPK24; NbExp=4; IntAct=EBI-537680, EBI-537551; O81439:PAP1; NbExp=5; IntAct=EBI-537680, EBI-962363; Q84MC7:PYL9; NbExp=3; IntAct=EBI-537680, EBI-2349513; O49686:PYR1; NbExp=3; IntAct=EBI-537680, EBI-2349590; Q84JG2:SWI3B; NbExp=2; IntAct=EBI-537680, EBI-1102271;
MiscellaneousThe reduced form of ABI2 is converted to the oxidized form by the addition of oxidized GPX3 or H(2)O(2).
SimilarityBelongs to the PP2C family. {ECO:0000305}.
SimilarityContains 1 PP2C-like domain. {ECO:0000305}.
SubunitInteracts with CIPK15/PKS3, GPX3, SCAR1, SCAR2, SCAR3 and SCARL. Interacts also with CIPK24/SOS2. Binds to the fibrillin precursor protein. Interacts with ABA-bounded PYR1, PYL1, PYL2, PYL3, PYL4, PYL5, PYL6, PYL8 and PYL9, and with free PYL2, PYL3 and PYL4. {ECO:0000269|PubMed:12194854, ECO:0000269|PubMed:14504388, ECO:0000269|PubMed:16571665, ECO:0000269|PubMed:16998070, ECO:0000269|PubMed:17267444, ECO:0000269|PubMed:19407142, ECO:0000269|PubMed:19407143, ECO:0000269|PubMed:19769575}.