LMPD Database

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LMP011131

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 2C
Protein EntryP2C32_ARATH
UniProt IDQ8RWN7
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Developmental StageExpressed throughout development of the floral meristem, in all four floral whorls and as floral organs matured, limited to the ovule. {ECO:0000269|PubMed:12573213}.
Disruption PhenotypeLoss-of-function mutant pol-6 (T-DNA insertion) shows suppression of clavata mutant phenotypes. The catalytic activity of POL may be functionally replaced by the activity of PLL1. Pol and pll1 double mutant is seedling lethal. {ECO:0000269|PubMed:16112663}.
DomainThe conserved PP2C phosphatase domain (271-833) is interrupted by an insertion of approximately 200 amino acids.
DomainThe N-terminal domain (1-233) has a regulatory function and inhibits phosphatase activity.
Enzyme RegulationInsensitive to okadaic acid. {ECO:0000269|PubMed:12573213}.
FunctionInvolved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems. {ECO:0000269|PubMed:10725242, ECO:0000269|PubMed:12573213, ECO:0000269|PubMed:16112663, ECO:0000269|PubMed:17079273}.
Sequence CautionSequence=AAC34239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the PP2C family. {ECO:0000305}.
SimilarityContains 1 PP2C-like domain. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
Tissue SpecificityExpressed in roots, leaves, stems, inflorescences, flowers and throughout the shoot meristem. {ECO:0000269|PubMed:12573213, ECO:0000269|PubMed:16112663}.