LMPD Database

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LMP010950

UniProt Annotations

Entry Information
Gene Nameprobable acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Protein EntryLPXA_ARATH
UniProt IDQ9SU91
SpeciesArabidopsis
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9SU91-1; Sequence=Displayed; Name=2; IsoId=Q9SU91-2; Sequence=VSP_045743; Note=No experimental confirmation available.;
Catalytic Activity(R)-3-hydroxytetradecanoyl-[acyl-carrier- protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier- protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D- glucosamine. {ECO:0000269|PubMed:22545860}.
Disruption PhenotypeNo visible phenotype under normal growth conditions, but plants lacking LPXA accumulate very low levels of 2,3-diacylglucosamine-1-phosphate. {ECO:0000269|PubMed:21709257}.
FunctionInvolved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential). {ECO:0000305}.
PathwayGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. {ECO:0000269|PubMed:21709257}.
SimilarityBelongs to the transferase hexapeptide repeat family. LpxA subfamily. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:21709257}.
SubunitHomotrimer. {ECO:0000269|PubMed:22545860}.