LMPD Database

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LMP010903

UniProt Annotations

Entry Information
Gene Namephosphopantetheine adenylyltransferase
Protein EntryCOAD_ARATH
UniProt IDQ9ZPV8
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=37 uM for 3'-dephospho-CoA {ECO:0000269|PubMed:18621975}; Vmax=0.34 umol/min/mg enzyme for the reverse reaction {ECO:0000269|PubMed:18621975};
Catalytic ActivityATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.
Disruption PhenotypePlants are severely impaired in plant growth and seed production, but almost not affected in the accumulation of total fatty acids per seed. {ECO:0000269|PubMed:18621975}.
Enzyme RegulationInhibited by CoA. {ECO:0000269|PubMed:18621975}.
FunctionReversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Does not accept 4'-phosphopantothenoylcysteine as a substrate. {ECO:0000269|PubMed:12860978, ECO:0000269|PubMed:18621975}.
PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
SimilarityBelongs to the eukaryotic CoaD family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.