LMPD Database

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LMP010896

UniProt Annotations

Entry Information
Gene Namephospholipid sterol acyl transferase 1
Protein EntryLCAT2_ARATH
UniProt IDQ4VCM1
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeEarly leaf senescence. Strong reduction in total sterol esters content in leaves and seeds. No change in flowers. {ECO:0000269|PubMed:16020547, ECO:0000269|PubMed:19923239}.
FunctionInvolved in lipid catabolism. Essential for sterol esters biosynthesis in leaves and seeds, but not in flowers. Plays a role in controlling the free sterol content of leaves. Catalyzes the transacylation of acyl groups from phospholipids to a variety of different sterols. Prefers phosphatidylethanolamine over phosphatidylcholine as an acyl donor. Not active toward neutral lipids. Highly specific for position sn-2, which in plant lipids is essentially devoid of saturated acyl groups. Broad sterol specificity (cholesterol > campesterol > sitosterol > stigmasterol), but no activity with lupeol or beta-amyrin. {ECO:0000269|PubMed:16020547, ECO:0000269|PubMed:19923239}.
InductionBy senescence. {ECO:0000269|PubMed:19923239}.
Sequence CautionSequence=AAD10668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000269|PubMed:16020547}; Single-pass type II membrane protein {ECO:0000269|PubMed:16020547}.