LMPD Database

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LMP010822

UniProt Annotations

Entry Information
Gene Nameinositol phosphorylceramide synthase 2
Protein EntryIPCS2_ARATH
UniProt IDQ9SH93
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeConstitutive RPW8-mediated HR-like cell death characterized by salicylic acid (SA) accumulation, enhanced transcription of RPW8 and RPW8-dependent spontaneous HR-like cell death (SHL) in leaf tissues. Reduced plant stature. Sphingolipid (e.g. ceramides and hydroxyceramides) accumulation associated with a reduced inositol-phosphorylceramide synthase (IPCS) activity. {ECO:0000269|PubMed:19001565}.
FunctionCatalyzes the transfer of the phosphorylinositol group from phosphatidylinositol (PI) to phytoceramide, an essential step in sphingolipid biosynthesis. May play an important role in modulating plant programmed cell death (PCD) associated with defense (e.g. toward Golovinomyces cichoracearum) by promoting sphingolipid metabolism and thus regulating ceramide accumulation. {ECO:0000269|PubMed:19001565, ECO:0000269|PubMed:20309609}.
InductionBy powdery mildew (e.g. Golovinomyces cichoracearum and Pseudomonas syringae) inoculation. {ECO:0000269|PubMed:19001565}.
SimilarityBelongs to the sphingomyelin synthase family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19001565}; Multi-pass membrane protein {ECO:0000269|PubMed:19001565}.
Tissue SpecificityExpressed in leaves, roots, stems, flowers and siliques. {ECO:0000269|PubMed:19001565, ECO:0000269|PubMed:20309609}.