LMPD Database

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LMP010778

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphohydrolase 1
Protein EntryPAH1_ARATH
UniProt IDQ9SF47
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:20699392};
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392};
Disruption PhenotypeNo visible phenotype under normal growth conditions, but the double mutants pah1 and pah2-1 show reduced growth. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392}.
DomainContains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
FunctionMagnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH2 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}.
Sequence CautionSequence=ACT37431.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the lipin family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol.
Tissue SpecificityExpressed in roots, leaves, stems, flowers, siliques, embryos and mature seeds. {ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}.