LMPD Database

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LMP010535

UniProt Annotations

Entry Information
Gene Namelipoxygenase 1
Protein EntryLOX1_ARATH
UniProt IDQ06327
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityLinoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy- 10,12-octadecadienoate. {ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:18949503}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. Iron is tightly bound. {ECO:0000255|PROSITE-ProRule:PRU00726};
Developmental StageTransiently expressed during germination, within 1 day after imbibition, especially in the epidermis and the aleurone layer. Later present in the epidermis of the radicle and the adaxial side of the cotyledons. In roots, confined to the pericycle cells and in the lateral root primordia (LRP), and declined at the time of lateral root emergence. Expression is greatly increased in leaves during leaf senescence. {ECO:0000269|PubMed:11891244, ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:17369372}.
Disruption PhenotypeIncrement in the number of lateral roots, and moderate increase in the length of the primary root. {ECO:0000269|PubMed:17369372}.
Function9S-lipoxygenase that can use linoleic acid or linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Function as regulators of root development by controlling the emergence of lateral roots. {ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:18949503}.
InductionBy pathogens (e.g. Pseudomonas syringae), wounding, abscisic acid (ABA) and methyl jasmonate (MeJA). Higher levels in light than in dark conditions. {ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:7506426}.
PathwayLipid metabolism; oxylipin biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00726}.
SimilarityBelongs to the lipoxygenase family. {ECO:0000305}.
SimilarityContains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationCytoplasm.
SubunitMonomer.
Tissue SpecificitySeedlings, roots, leaves, and flowers (at protein level). {ECO:0000269|PubMed:12232208, ECO:0000269|PubMed:17369372, ECO:0000269|PubMed:7506426, ECO:0000269|Ref.7}.