LMPD Database

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LMP010498

UniProt Annotations

Entry Information
Gene Nameprotein MODIFIED VACUOLE PHENOTYPE 1
Protein EntryGDL21_ARATH
UniProt IDQ7XA74
SpeciesArabidopsis
Comments
Comment typeDescription
CautionLacks the conserved active site 'GDSL' motif and has no lipase activity. {ECO:0000305}.
Developmental StageExpressed during all developmental stages, with the highest accumulation in germinated seeds. {ECO:0000269|PubMed:19880612}.
Disruption PhenotypeDefects in endoplasmic reticulum (ER) protein export and organizational defects in the ER, including aggregation of ER around the nucleus. Increased sensitivity to salt. {ECO:0000269|PubMed:19880612, ECO:0000269|PubMed:20626647, ECO:0000269|PubMed:23155454}.
FunctionInvolved in organization of the endomembrane system and is required for endoplasmic reticulum morphology and organelle distribution. May act by inhibiting the formation of PYK10 complex by binding to GLL23 and exporting it from the ER. Required for proper subcellular localization of myrosinase TGG2. Has no lipase or esterase activity. {ECO:0000269|PubMed:19880612, ECO:0000269|PubMed:20626647, ECO:0000269|PubMed:23155454, ECO:0000269|PubMed:24330158}.
InductionUp-regualted by methyl jasmonate and upon pathogen infection. {ECO:0000269|PubMed:19880612}.
Sequence CautionSequence=AAD25775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAM65534.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM65534.1; Type=Miscellaneous discrepancy; Note=The stop codon at position 16 is created by sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. {ECO:0000305}.
Subcellular LocationVacuole. Endoplasmic reticulum. Note=Also found in ER bodies. Retained in the ER when mutated.
SubunitInteracts with the PYK10 complex and TGG2, but not with TGG1 or PEN2. {ECO:0000269|PubMed:19880612, ECO:0000269|PubMed:23155454}.
Tissue SpecificityExpressed throughout the seedling, rosette leaves, roots, inflorescence and imbibed seed, but not in pollen. {ECO:0000269|PubMed:19880612}.