LMPD Database

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LMP010487

UniProt Annotations

Entry Information
Gene Namehomogentisate phytyltransferase 1
Protein EntryHPT1_ARATH
UniProt IDQ8VWJ1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityPhytyl diphosphate + homogentisate = diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO(2). {ECO:0000269|PubMed:16989822}.
Disruption PhenotypeReduced seed longevity, severe seedling growth defects during germination and high levels of lipid hydroperoxides and hydroxy fatty acids. {ECO:0000269|PubMed:12586887}.
FunctionInvolved in the synthesis of tocopherol (vitamin E). Catalyzes the condensation of homogentisate and phytyl diphosphate to form dimethylphytylhydrquinone. Low activity with geranylgeranyl diphosphate as substrate, but no activity with farnesyl diphosphate or solanesyl diphosphate. Tocopherol functions to limit lipid oxidation during seed desiccation, quiescence and germination and early seedling development. Protects thylakoid membrane lipids from photooxidation and is required for low-temperature adaptation. {ECO:0000269|PubMed:11706191, ECO:0000269|PubMed:12011362, ECO:0000269|PubMed:12586887, ECO:0000269|PubMed:16258032, ECO:0000269|PubMed:16989822, ECO:0000269|PubMed:17012603, ECO:0000269|PubMed:18314499, ECO:0000269|PubMed:20691023, ECO:0000269|PubMed:20837525, ECO:0000269|PubMed:21223386}.
MiscellaneousSeeds and plants overexpressing HPT1 accumulate increased levels of tocopherol.
PathwayCofactor biosynthesis; tocopherol biosynthesis.
Sequence CautionSequence=AAC09029.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular LocationPlastid, chloroplast membrane {ECO:0000269|PubMed:21223386}; Multi-pass membrane protein {ECO:0000255}.