LMPD Database

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LMP010396

UniProt Annotations

Entry Information
Gene Nameglucose-6-phosphate acetyltransferase 1
Protein EntryGNA1_ARATH
UniProt IDQ9LFU9
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=33 uM for acetyl-coenzyme A {ECO:0000269|PubMed:22329777}; KM=231 uM for glucosamine-6-phosphate {ECO:0000269|PubMed:22329777}; pH dependence: Optimum pH is 7.0-8.0. {ECO:0000269|PubMed:22329777}; Temperature dependence: Optimum temperature is 35 degrees Celsius. {ECO:0000269|PubMed:22329777};
Catalytic ActivityAcetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate. {ECO:0000269|PubMed:22329777}.
Disruption PhenotypeRetarded vegetative growth, delayed flowering and short and thick inflorescence stems and siliques. {ECO:0000269|PubMed:22932674}.
FunctionAcetyltransferase involved in UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis. UDP-GlcNAc is an essential metabolite that serves as an initial sugar donor for N-glycan synthesis and thus plays an important role in protein and lipid glycosylation. {ECO:0000269|PubMed:22329777, ECO:0000269|PubMed:22932674}.
MiscellaneousThe mutant lignescens (lig) was originally isolated as a temperature-sensitive mutant that exhibits ectopic lignin deposition and growth defects under high-temperature conditions. {ECO:0000305|PubMed:22932674}.
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.
SimilarityBelongs to the acetyltransferase family. GNA1 subfamily. {ECO:0000305}.
SimilarityContains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule:PRU00532}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:22329777}; Peripheral membrane protein {ECO:0000269|PubMed:22329777}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityExpressed in roots, leaves, stems, cauline leaves, flowers and siliques. {ECO:0000269|PubMed:22329777}.