LMPD Database

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LMP010149

UniProt Annotations

Entry Information
Gene NameDNA topoisomerase 6 subunit A
Protein EntryTOP6A_ARATH
UniProt IDQ9LZ03
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO:0000255|HAMAP-Rule:MF_03164}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_03164};
Disruption PhenotypePlants are defective in cell elongation and show a severe dwarf phenotype. {ECO:0000269|PubMed:12401175}.
FunctionComponent of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Involved in cell-elongation processes. {ECO:0000255|HAMAP-Rule:MF_03164, ECO:0000269|PubMed:12119417, ECO:0000269|PubMed:12401175}.
InteractionO81242:RHL1; NbExp=2; IntAct=EBI-1772104, EBI-1772159; Q9C5V6:TOP6B; NbExp=3; IntAct=EBI-1772104, EBI-1772132;
SimilarityBelongs to the TOP6A family. {ECO:0000255|HAMAP- Rule:MF_03164}.
Subcellular LocationNucleus {ECO:0000255|HAMAP-Rule:MF_03164}.
SubunitHomodimer. Heterotetramer of two TOP6A and two TOP6B subunits. Interacts with BIN4 and RHL1. {ECO:0000255|HAMAP- Rule:MF_03164, ECO:0000269|PubMed:11410368, ECO:0000269|PubMed:16339310, ECO:0000269|PubMed:17951446, ECO:0000269|PubMed:18055605}.
Tissue SpecificityHighly expressed in leaves, stems, flowers and seedlings. {ECO:0000269|PubMed:11410368}.