LMPD Database

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LMP010075

UniProt Annotations

Entry Information
Gene Namecytochrome P450 734A1
Protein EntryC734A_ARATH
UniProt IDO48786
SpeciesArabidopsis
Comments
Comment typeDescription
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Disruption PhenotypeNo visible phenotype under normal growth condition, but reduced responsiveness of hypocotyls to light and increased responsiveness to brassinolide. Strong reduction of C-26 hydroxylase activity. {ECO:0000269|PubMed:14605216, ECO:0000269|PubMed:15773851}.
FunctionCytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Inactivates the BRs castasterone and brassinolide through carbon 26 hydroxylation. Acts in association with CYP72C1 to inactivate BRs and modulate photomorphogenesis. {ECO:0000269|PubMed:10611382, ECO:0000269|PubMed:14605216, ECO:0000269|PubMed:15773851, ECO:0000269|PubMed:20396969, ECO:0000269|PubMed:20669042}.
InductionBy brassinolide, auxin and dark treatment. {ECO:0000269|PubMed:14605216, ECO:0000269|PubMed:20396969}.
MiscellaneousPlants overexpressing CYP734A1 exhibit severe dwarfism.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.