LMPD Database

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LMP010070

UniProt Annotations

Entry Information
Gene Namecytochrome P450 710A2
Protein EntryC7102_ARATH
UniProt IDO64698
SpeciesArabidopsis
Comments
Comment typeDescription
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Disruption PhenotypeNo visible phenotype under normal growth conditions, but production of brassicasterol is abolished. {ECO:0000269|PubMed:16531502}.
FunctionRequired to form the C-22 double bond in the sterol side chain. Possesses in vitro C-22 desaturase activity toward 24-epi- campesterol and beta-sitosterol and produces brassicasterol and stigmasterol, respectively. {ECO:0000269|PubMed:16531502}.
MiscellaneousPlants overexpressing CYP710A2 show higher levels of brassicasterol/crinosterol and stigmasterol, and lower levels of 24-epi-campesterol/campesterol and beta-sitosterol than the wild-type.
PathwaySteroid biosynthesis; sterol biosynthesis.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in the vascular tissues of roots, shoots, stems and leaves. Expressed in root tips, carpes, siliques and seeds. {ECO:0000269|PubMed:16531502}.