LMPD Database

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LMP009959

UniProt Annotations

Entry Information
Gene NameBRI1 kinase inhibitor 1
Protein EntryBKI1_ARATH
UniProt IDQ9FMZ0
SpeciesArabidopsis
Comments
Comment typeDescription
DomainThe c-terminal part (253-337) is necessary and sufficient for the interaction with BRI1.
FunctionNegative regulator of brassinosteroid signaling. When associated to the membrane, limits the interaction of BRI1 with BAK1 by binding to the kinase-inactive form of BRI1. {ECO:0000269|PubMed:16857903}.
InteractionQ9ZWC8:BRL1; NbExp=4; IntAct=EBI-1111615, EBI-590903;
MiscellaneousBRI1 is not required for BKI1 association with the plasma membrane, but the BRI1 kinase activity is necessary for the membrane release.
PtmPhosphorylated on Tyr-211 in response to brassinosteroid perception, leading to its inactivation: once phosphorylated, displaced into the cytosol where it is inactive. {ECO:0000269|PubMed:16857903, ECO:0000269|PubMed:21289069}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:21289069}. Cytoplasm {ECO:0000269|PubMed:21289069}. Note=Once phosphorylated following brassinosteroid treatment, displaced from the plasma membrane into the cytosol where it is inactive.
SubunitInteracts (via C-terminus) with BRI1 (via kinase domain). {ECO:0000269|PubMed:16857903}.
Tissue SpecificityExpressed in leaves, petioles, shoot apices, hypocotyls, roots and flowers. {ECO:0000269|PubMed:16857903}.