LMPD Database

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LMP009891

UniProt Annotations

Entry Information
Gene Nameautophagy-related protein 8b
Protein EntryATG8B_ARATH
UniProt IDQ9XEB5
SpeciesArabidopsis
Comments
Comment typeDescription
FunctionUbiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. May mediate the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity). {ECO:0000250}.
PtmThe C-terminal 5 residues are removed by ATG4 to expose Gly- 117 at the C-terminus. This Gly-117 forms then a thioester bond with the 'Cys-558' of ATG7 (E1-like activating enzyme) before being transferred to the 'Cys-258' of ATG3 (the specific E2 conjugating enzyme), in order to be finally amidated with phosphatidylethanolamine. This lipid modification anchors ATG8 to autophagosomes (By similarity). {ECO:0000250}.
SimilarityBelongs to the ATG8 family. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle, cvt vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Vacuole membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Membrane-associated through a lipid anchor. {ECO:0000250}.
SubunitInteracts with ATG4. {ECO:0000250}.
Tissue SpecificityContitutively expressed. {ECO:0000269|PubMed:15494556}.