LMPD Database

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LMP009882

UniProt Annotations

Entry Information
Gene NameATP citrate lyase subunit B 2
Protein EntryACLB2_ARATH
UniProt IDQ9FGX1
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
Developmental StageExpressed in flower buds at stage 6 of development in tapetal cells and at stage 10 in the epidermal cells of growing petals and ovaries. In young siliques, expressed transiently in the inner integument of the ovules just prior to testal deposition. Expressed in the developing embryo with a maximal level at the heart and torpedo stages. The expression then disappears in the mature embryo. During seed germination, expressed in the vascular bundles, apical meristem, epidermis of the seedling cotyledon, stem, and root. Highly expressed in the root tip of seedlings 4 days after imbibition. {ECO:0000269|PubMed:12376641}.
FunctionATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. n contrast to all known animal ACL enzymes having a homomeric structure, plant ACLs are composed of alpha and beta chains. {ECO:0000269|PubMed:12376641}.
SimilarityBelongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:12376641}.
SubunitHeterooctamer of 4 alpha and 4 beta chains. {ECO:0000305|PubMed:12376641}.
Tissue SpecificityExpressed in trichomes, epidermal leaf cells, anther tapetal cells, stigma and in young vascular bundles of expanding leaves, cotyledons, roots, pedicel of flowers and siliques. {ECO:0000269|PubMed:12376641}.