LMPD Database

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LMP009684

UniProt Annotations

Entry Information
Gene Name3-deoxy-manno-octulosonate cytidylyltransferase
Protein EntryKDSB_ARATH
UniProt IDQ9C920
SpeciesArabidopsis
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 9.5. {ECO:0000269|PubMed:21893514};
Catalytic ActivityCTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. {ECO:0000269|PubMed:19914588}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
FunctionCatalyzes the production of the sugar nucleotide CMP-3- deoxy-D-manno-octulosonate (CMP-KDO). CTP is the preferred nucleotide donor, but it can partially be replaced with UTP. Activates KDO during the biosynthesis of rhamnogalacturonan II (RG-II), a structurally complex pectic polysaccharide of the primary cell wall. RG-II is essential for the cell wall integrity of rapidly growing tissues and pollen tube growth and elongation. {ECO:0000269|PubMed:19914588, ECO:0000269|PubMed:21893514}.
MiscellaneousRhamnogalacturonan II (RG-II) RG-II is a structurally complex pectic polysaccharide present in the primary cell wall. RG-II consists of a linear 1,4-linked a-Dgalacturonic acid backbone with four distinct side chains, two of which contain apiosyl residues. Boric acid forms a diester with two apiosyl residues from separate RG-II molecules, thereby covalently cross- linking two RG-II molecules as a dimer.
PathwayNucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno- octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.
SimilarityBelongs to the KdsB family. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000305|PubMed:21893514, ECO:0000305|PubMed:21896887}; Peripheral membrane protein {ECO:0000305|PubMed:21893514, ECO:0000305|PubMed:21896887}.
Tissue SpecificityExpressed in roots, leaves, stems and siliques. {ECO:0000269|PubMed:19914588}.