LMPD Database

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LMP009634

UniProt Annotations

Entry Information
Gene Name1,4-Dihydroxy-2-naphthoyl-CoA synthase
Protein EntryMENB_ARATH
UniProt IDQ8GYN9
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4- dihydroxy-2-naphthoyl-CoA + H(2)O.
CofactorName=bicarbonate; Xref=ChEBI:CHEBI:17544; Evidence={ECO:0000250}; Note=The bicarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. {ECO:0000250};
FunctionInvolved in the biosynthesis of phylloquinone (vitamin K1). Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA) (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAB71952.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. {ECO:0000305}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:17951448, ECO:0000269|PubMed:20150517}.
SubunitHomohexamer. {ECO:0000250}.