LMPD Database

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LMP009168

UniProt Annotations

Entry Information
Gene NameCG16988 gene product from transcript CG16988-RA
Protein EntryRBX1B_DROME
UniProt IDQ9NHX0
SpeciesDrosophila
Comments
Comment typeDescription
CautionIt is uncertain whether Met-1 or Met-16 is the initiator. {ECO:0000305}.
DomainThe RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion (By similarity). {ECO:0000250}.
FunctionComponent of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). {ECO:0000250}.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=AAF32313.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the RING-box family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationCytoplasm. Nucleus.
SubunitPart of a SCF complex consisting of Skpa (SKP1), Lin19 (CUL1), Roc1B and a F-box protein. {ECO:0000250}.
Tissue SpecificityHighly expressed in early embryos, and in pupae. Widely expressed in adult males, while it is weakly expressed in adult females. {ECO:0000269|PubMed:12062088}.