LMPD Database

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LMP009132

UniProt Annotations

Entry Information
Gene NameNiemann-Pick type C-2a
Protein EntryNPC2_DROME
UniProt IDQ9VQ62
SpeciesDrosophila
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically. {ECO:0000269|PubMed:17804599}.
Disruption PhenotypeAbnormal sterol distribution in many cells, also lower than normal ecdysteroid levels. Npc2a and Npc2b double mutants undergo apoptotic neurodegeneration. {ECO:0000269|PubMed:17804599}.
FunctionFunctions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate. {ECO:0000269|PubMed:17804599}.
InteractionQ9VPU1:dock; NbExp=1; IntAct=EBI-183186, EBI-189398;
SimilarityBelongs to the NPC2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000305}.
Tissue SpecificityBroadly expressed with a higher level of expression in many tissues, including midgut, salivary gland and ventral nerve cord. {ECO:0000269|PubMed:17804599}.