LMPD Database

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LMP008985

UniProt Annotations

Entry Information
Gene NameCG5686 gene product from transcript CG5686-RB
Protein EntryQ9XTN2_DROME
UniProt IDQ9XTN2
SpeciesDrosophila
Comments
Comment typeDescription
Developmental StageExpressed during G1, S and G2 phase of the cell cycle. {ECO:0000269|PubMed:10399915}.
Disruption PhenotypeFemale sterile. Extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. {ECO:0000269|PubMed:11292874, ECO:0000269|PubMed:15890189}.
FunctionActivates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation. {ECO:0000250, ECO:0000269|PubMed:10399915, ECO:0000269|PubMed:10801879, ECO:0000269|PubMed:11292874, ECO:0000269|PubMed:15890189}.
InteractionP09208:InR; NbExp=3; IntAct=EBI-176370, EBI-92063;
Miscellaneous'Chico' means 'small boy' in Spanish. {ECO:0000305}.
Sequence CautionSequence=AAD55429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 1 IRS-type PTB domain. {ECO:0000255|PROSITE- ProRule:PRU00389}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SubunitBindings to phosphatidylinositol 3-kinase and SHP2.