LMPD Database

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LMP008139

UniProt Annotations

Entry Information
Gene NameProtein NRF-6
Protein EntryNRF6_CAEEL
UniProt IDQ09225
SpeciesC. elegans
Comments
Comment typeDescription
Disruption PhenotypeIncreased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defective yolk transport to the oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid- induced sterility. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504}.
FunctionPlays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504}.
SimilarityBelongs to the acyltransferase 3 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityIn L1 larvae through to adult, hyp3 and hyp5, the most anterior cells in the hypodermis, and in intestine. Other hypodermal cells show weaker expression. {ECO:0000269|PubMed:10488330}.