LMPD Database

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LMP008122

UniProt Annotations

Entry Information
Gene NameProtein SQV-2
Protein EntrySQV2_CAEEL
UniProt IDQ9N491
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + 4-beta-D-galactosyl-O- beta-D-xylosyl-[protein] = UDP + 3-beta-D-galactosyl-4-beta-D- galactosyl-O-beta-D-xylosyl-[protein]. {ECO:0000269|PubMed:12584198}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Disruption PhenotypeWorms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell. {ECO:0000269|PubMed:12584198}.
FunctionBeta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis. {ECO:0000269|PubMed:12584198}.
PathwayGlycan metabolism; chondroitin sulfate biosynthesis.
PathwayGlycan metabolism; heparan sulfate biosynthesis.
SimilarityBelongs to the glycosyltransferase 31 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.