LMPD Database

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LMP008039

UniProt Annotations

Entry Information
Gene NameProtein PEPT-1
Protein EntryPEPT1_CAEEL
UniProt IDQ21219
SpeciesC. elegans
Comments
Comment typeDescription
Developmental StageBiphasic expression pattern observed. Gradual increase in expression during development from embryo through to adult with a decrease during larva stages 1 and 2. {ECO:0000269|PubMed:9601088}.
Disruption PhenotypeMutant worms have decreased body size, high fat stores, increased uptake of fatty acids, reduced brood size, retarded postembryonic growth, extended reproductive life span and increased resistance to stress. RNAi-mediated knockdown of the protein results in impaired synthesis of long-chain and polyunsaturated fatty acids. Pharyngeal pumping rate is similar to wild type but simultaneous knockdown with nhx-2 results in reduced rate of pharyngeal pumping and slightly higher acidic intestinal pH. {ECO:0000269|PubMed:12939266, ECO:0000269|PubMed:15155758, ECO:0000269|PubMed:18676815, ECO:0000269|PubMed:19621081, ECO:0000269|PubMed:19844570, ECO:0000269|PubMed:20550516}.
FunctionLow-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx- 2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism. {ECO:0000269|PubMed:12939266, ECO:0000269|PubMed:15155758, ECO:0000269|PubMed:19621081, ECO:0000269|PubMed:20550516, ECO:0000269|PubMed:21275419, ECO:0000269|PubMed:21980510, ECO:0000269|PubMed:9601088}.
Sequence CautionSequence=AAC39119.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};
SimilarityBelongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO:0000305}.
Subcellular LocationApical cell membrane {ECO:0000269|PubMed:12939266, ECO:0000269|PubMed:21980510}; Multi- pass membrane protein {ECO:0000269|PubMed:12939266, ECO:0000269|PubMed:21980510}. Note=Colocalizes with nhx-2 along the apical membrane of the intestinal cells.
Tissue SpecificityExpressed specifically in the intestine. {ECO:0000269|PubMed:12939266}.